Hydrochloric Acid → tert-butyl (4S)-4-{[(benzyloxy)carbonyl]amino}-5-oxo-5-[(3-oxopropyl)amino]pentanoate

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Reaction Steps

By using an analogous procedure to that described for Reference Example 14, tert-butyl (4S)-4-{[(benzyloxy)carbonyl]amino}-5-[(3,3-diethoxypropyl)amino]-5-oxopentanoate (2.75 g, 5.9 mmol, obtained from Reference Example 25) in tetrahydrofuran (12 ml) was reacted with 0.5 N hydrochloric acid (12 ml) for 1 hour at room temperature, to provide tert-butyl (4S)-4-{[(benzyloxy)carbonyl]amino}-5-oxo-5-[(3-oxopropyl)amino]pentanoate (2.1 g, 91%) as a pale yellow solid.

Provenance & Evidence