N-Acetyl-4-piperidone → 1-acetyl-4-(N-(4-fluorobenzyl)-N-methylamino)piperidine

HRID 257081Notes

Reaction equation

HRID 257081 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[F:11][C:12]1[CH:20]=[CH:19][C:15]([CH2:16][NH:17][CH3:18])=[CH:14][CH:13]=1>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:17]([CH2:16][C:15]2[CH:19]=[CH:20][C:12]([F:11])=[CH:13][CH:14]=2)[CH3:18])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 122563N-Acetyl-4-piperidoneHCID 7368601-(4-fluorophenyl)-N-methylmethanamine

Product 1

HCID 197843741-acetyl-4-(N-(4-fluorobenzyl)-N-methylamino)piperidineYield 67.8%

Procedure

17.1 g (0.14 mol) of N-acetyl-4-piperidone and 16.9 g (0.14 mol) of N-(4-fluorobenzyl)-N-methylamine were reacted in a similar manner to Preparation 6. 25.1 g of 1-acetyl-4-(N-(4-fluorobenzyl)-N-methylamino)piperidine were obtained.

Sources & evidence

ORD record
ord-b08d88381dd14505a7c8299a43546274
Source dataset
uspto-grants-1993_11
Patent number
US05260318

Reaction notes

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