HCID 57318325, compound → HCID 19784381, compound

Participants

Reaction Steps

5.5 g (16.3 mmol) of the product from Example 7 were refluxed in a mixture of 100 ml of 2M sodium hydroxide solution and 200 ml of methanol for 12 h. The reaction mixture was then concentrated under reduced pressure, the residue was partitioned between water and methylene chloride, and the organic phase was dried and concentrated under reduced pressure. 2.8 g of 1-(4-aminophenyl)-4-(N-benzyl-N-methylamino)piperidine were obtained as an oil which crystallized as difumarate. Melting point 138° C.

Provenance & Evidence