Sodium borohydride → HCID 67854747, compound

Participants

Reaction Steps

10.4 g (0.32 mol) of the product from Example 12 (as base) were dissolved in 500 ml of methanol and, at 10° C., 18.0 g (0.475 mol) of sodium borohydride were added a little at a time. The mixture was stirred at room temperature for 16 hours and then evaporated in a rotary evaporator. The residue was partitioned between methylene chloride and water, and the organic phase was dried and evaporated in a rotary evaporator. The resulting oil was crystallized as the fumarate. 16.4 g of 1-(4-(1-hydroxyethyl)phenyl)-4-(N-methyl-N-(2-phenylethyl)amino)piperidine difumarate were obtained. Melting point 124°-129° C.

Provenance & Evidence