Trifluoroacetic acid → HCID 19784379, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.1 g (15 mmol) of the product from Example 13, 2.6 g (22.5 mmol) of triethylsilane and 17.1 g (15 mmol) of trifluoroacetic acid was heated at 60° C. for 2 hours. The mixture was then poured into water, made alkaline with 4M sodium hydroxide solution and extracted with methylene chloride. The organic phase was separated off, dried and evaporated in a rotary evaporator. The resulting residue was purifed by chromatography on silica gel (eluent: toluene/acetone=2/1). The oily product crystallized as the fumarate. 1.5 g of 1-(4-ethylphenyl)-4-(N-methyl-N-(2-phenylethyl)amino)piperidine fumarate were obtained. Melting point 163°-165° C.

Provenance & Evidence