Diethyl Ether → HCID 19784348, compound

Participants

Reaction Steps

2.5 g (7.9 mmol)of the product from Example 17 were dissolved in 50 ml of glacial acetic acid and, at room temperature, 1.26 g (7.9 mmol) of bromine dissolved in 10 ml of glacial acetic acid were added dropwise. The mixture was stirred for 4 hours, after which ether was added, whereupon crystals slowly separated out. The crystals were filtered off and washed with ether. 3.5 g of 1-(4-acetyl-2-bromophenyl)-4-(N-benzyl-N-methylamino)piperidine hydrobromide were obtained. Melting point 201°-202° C.

Provenance & Evidence