2-Fluorobenzoyl chloride → HCID 3438030, compound

HRID 257157Notes

Reaction equation

HRID 257157 reaction equation
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](Cl)=[O:11]>C(Cl)(Cl)Cl>[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([NH:5][NH:4][C:3]([NH:2][CH3:1])=[S:6])=[O:11]

Participants

4

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 2723853N-Methylhydrazinecarbothioamide

Product 1

HCID 3438030HCID 3438030, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a stirred room temperature suspension of 4-methylthiosemicarbazide (7.9 g, 7.5×10-2 mole) and CHCl3 (190 ml), 2-fluorobenzoyl chloride (9.4 ml, 7.9×10-2 mole) was added dropwise. After stirring overnight at room temperature, the precipitate was collected by filtration and the product was washed with two portions of Et2O. Drying by suction gave a colorless powder which was used without further purification in the subsequent cyclization step.

Workup

  1. additionwas added dropwise
  2. filtrationthe precipitate was collected by filtration
  3. washthe product was washed with two portions of Et2O
  4. customDrying by suction
  5. customgave a colorless powder which
  6. customwas used without further purification in the subsequent cyclization step

Sources & evidence

ORD record
ord-e1f11bf6f284453ba0fdc53a0a70ee9c
Source dataset
uspto-grants-1993_11
Patent number
US05260450

Reaction notes

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