Glutaric anhydride → HCID 14855761, compound

Participants

Reaction Steps

5 mmoles of 5-(n-hexyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine 69 are reacted in 20 ml of CH2Cl2 with 5 mmoles (0.5 g) of glutaric acid anhydride and 11 mmoles (1.47 g) of AlCL3 similarly to the procedure for preparing the 5-(diphenyl-2,3-dihydro-1H-pyrrolizinyl)-5-oxovaleric-acids. The product is purified by column chromatography (silica gel, 1st n-hexane/ether 1+1, 2nd ether). After the eluates are concentrated, 71 remains as an oil.

Provenance & Evidence