Acetic Acid → HCID 14405001, compound

HRID 257231Notes

Reaction equation

HRID 257231 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11].C(O)(=O)C.[N+:16]([O-])([OH:18])=[O:17]>ClCCl>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([N+:16]([O-:18])=[O:17])[C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 944Nitric AcidHCID 27825072,6-dichloro-3,5-difluorophenol

Product 1

HCID 14405001HCID 14405001, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

20 g of 2,6-dichloro-3,5-difluorophenol are introduced into 70 ml of acetic acid, and 8 g of 98% strength nitric acid are added dropwise. The mixture is subsequently stirred for a further 2 hours at room temperature and taken up in 150 ml of dichloromethane, and the solution is washed twice with water. After removing the dichloromethane by distillation, 18 g of product remain. 94% purity according to GC analysis.

Workup

  1. additionare added dropwise
  2. washthe solution is washed twice with water
  3. customAfter removing the dichloromethane
  4. distillationby distillation, 18 g of product

Sources & evidence

ORD record
ord-ea06658fa5aa4b67a80ea6d01647b260
Source dataset
uspto-grants-1993_11
Patent number
US05260474

Reaction notes

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