HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Acetanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | Dibutyltin dichloride | HCID 12688 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Acetanilide | HCID 904 | 97% |
Reaction Steps
1.19 g phenyl isocyanate was reacted with 0.6 g acetic acid in a 1:1 molar ratio in the presence of dibutyltin dichloride in methylene chloride (20 parts). The molar ratio of dibutyltin dichloride to phenyl isocyanate was 1:100. The reaction, product isolation and analysis were conducted as in Example 1. A 97.0% yield of acetanilide was obtained (1.20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05260483 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-ac856e70cdc746d791a50962fe422218 |
| Source note | uspto-grants-1993_11 |