Methyl iodide → 3-Fluoro-4-nitroanisole

Participants

Reaction Steps

A mixture 25.0 g (0.16 mole) of 3-fluoro-4-nitrophenol, 27.6 g (0.20 mole) of potassium carbonate, and 28.4 g (0.20 mole) of methyl iodide in 2-butanone was heated at 70° C. for approximately 17 hours. The reaction mixture was then poured over ice and extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate, and filtered. The filtrate was evaporated under reduced pressure, leaving 24.35 g of 3-fluoro-4-nitroanisole as a solid residue. The NMR spectrum was consistent with the proposed structure. This product was used in Step B without further purification.

Provenance & Evidence