3-Fluoro-4-nitroanisole → 2-Fluoro-4-methoxyaniline

HRID 257360ノート

反応式

HRID 257360 の反応式
[F:1][C:2]1[CH:3]=[C:4]([O:11][CH3:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O.[H][H]>C(O)C.[Pt]=O>[F:1][C:2]1[CH:3]=[C:4]([O:11][CH3:12])[CH:5]=[CH:6][C:7]=1[NH2:8]

参加物

5

反応物 2

HCID 5656543-Fluoro-4-nitroanisoleHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 37563832-Fluoro-4-methoxyaniline

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

All of the product from Step A was placed in a Parr hydrogenation apparatus, and 0.35 g of platinum oxide in 200 mL of ethanol was added. This mixture was reacted with hydrogen until the theoretical amount of hydrogen was absorbed. The reaction was stopped, and the reaction mixture was filtered through Celite® filter aid. The solvent was then evaporated under reduced pressure, leaving 18.5 g of 2-fluoro-4-methoxyaniline as a solid residue.

後処理

  1. additionwas added
  2. customwas absorbed
  3. filtrationthe reaction mixture was filtered through Celite®
  4. filtrationfilter aid
  5. customThe solvent was then evaporated under reduced pressure

出典と根拠

ORDレコード
ord-1053126d21ac407a8d9bd7dbf4e0a32c
出典データセット
uspto-grants-1993_11
特許番号
US05262390

反応ノート

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