4-Ethylpyridine → 1-(2-Fluorophenyl)-4-(4-pyridyl)-pentane

HRID 257478Notes

Reaction equation

HRID 257478 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2].Br[CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[F:19]>>[F:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[CH2:12][CH2:11][CH2:10][CH:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 108224-EthylpyridineHCID 148837821-(3-Bromopropyl)-2-fluorobenzene

Product 1

HCID 148837861-(2-Fluorophenyl)-4-(4-pyridyl)-pentaneYield 71.9%

Procedure

1.62 g (15.1 mmol) of 4-ethylpyridine and 3.3 g (15.1 mmol) of 1-bromo-3-(2-fluorophenyl)-propane were reacted in the same manner as in Example 26. The reaction product was purified to obtain 2.64 g of the desired compound (yield: 71.6%). The resulting compound was identified as 1-(2-fluorophenyl)-4-(4-pyridyl)-pentane (hereinafter referred to as compound 40) by the following analytical results.

Workup

  1. customThe reaction product was purified

Sources & evidence

ORD record
ord-d2740e3bac7f40afa2cf2bbb23c448dc
Source dataset
uspto-grants-1993_11
Patent number
US05262420

Reaction notes

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