反应详情

温度

120 °C

A mixture of 10 g of 2-methoxy-4′-aminobiphenyl, 4.4 g of iodine, 44 g of magnesium sulfate and 600 mL of acetone was heated in a sealed flask at 120° C. overnight. The reaction mixture was cooled down to room temperature and filtered through diatomaceous earth. The residue was rinsed with acetone and the solvent was evaporated in vacuo. The residue was purified by flash chromatography to yield 2.4 g of 6-(2-methoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline as a foam.

1. temperatureThe reaction mixture was cooled down to room temperature
2. filtrationfiltered through diatomaceous earth
3. washThe residue was rinsed with acetone
4. customthe solvent was evaporated in vacuo
5. customThe residue was purified by flash chromatography