(3-Bromopropyl)benzene → 1-Phenyl 4-(3-methyl-4-pyridyl)-pentane

HRID 257481Notes

Reaction equation

HRID 257481 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][CH3:9].Br[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:14]1([CH2:13][CH2:12][CH2:11][CH:8]([C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[CH3:1])[CH3:9])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 12503(3-Bromopropyl)benzeneHCID 34088Pyridine, 4-ethyl-3-methyl-

Product 1

HCID 148837891-Phenyl 4-(3-methyl-4-pyridyl)-pentaneYield 38.8%

Procedure

1.83 g (15.1 mmol) of 3-methyl 4-ethylpyridine and 3.0 g (15.1 mmol) of 1-bromo-3-phenylpropane were reacted in the same manner as in Example 26. The reaction product was purified to obtain 1.40 g of the desired compound (yield: 38.8%).

Workup

  1. customThe reaction product was purified

Sources & evidence

ORD record
ord-342af8bf728f4974a7da1604105b157e
Source dataset
uspto-grants-1993_11
Patent number
US05262420

Reaction notes

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