3-Ethyl-4-methylpyridine → 1-(2-Chlorophenyl)-4-(3-ethyl-4-pyridyl)-butane

HRID 257482Notes

Reaction equation

HRID 257482 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[CH3:9])[CH3:2].Br[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20]>>[Cl:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[CH2:13][CH2:12][CH2:11][CH2:9][C:8]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[CH2:1][CH3:2]

Participants

3

Reactant 2

HCID 682543-Ethyl-4-methylpyridineHCID 2941151-(3-Bromopropyl)-2-chlorobenzene

Product 1

HCID 148837901-(2-Chlorophenyl)-4-(3-ethyl-4-pyridyl)-butaneYield 39.2%

Procedure

1.83 g (15.1 mmol) of 3-ethyl-4-methylpyridine and 3.53 g (15.1 mmol) of 1-bromo-3-(2-chlorophenyl)-propane were reacted in the same manner as in Example 26. The reaction product was purified to obtain 1.62 g of the desired compound (yield: 39.1%).

Workup

  1. customThe reaction product was purified

Sources & evidence

ORD record
ord-ecd97080d3f64734aec2401b655d0512
Source dataset
uspto-grants-1993_11
Patent number
US05262420

Reaction notes

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