3-Ethyl-4-methylpyridine → 1-(3-Chlorophenyl)-4-(3-ethyl-4-pyridyl)butane

HRID 257483Notes

Reaction equation

HRID 257483 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[CH3:9])[CH3:2].Br[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=1>>[Cl:20][C:16]1[CH:15]=[C:14]([CH2:13][CH2:12][CH2:11][CH2:9][C:8]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[CH2:1][CH3:2])[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 682543-Ethyl-4-methylpyridineHCID 140848601-(3-Bromopropyl)-3-chlorobenzene

Product 1

HCID 148837911-(3-Chlorophenyl)-4-(3-ethyl-4-pyridyl)butaneYield 61%

Procedure

1.83 g (15.1 mmol) of 3-ethyl-4-methylpyridine and 3.53 g (15.1 mmol) of 1-bromo-3-(3-chlorophenyl)-propane were reacted in the same manner as in Example 26. The reaction product was purified to obtain 2.52 g of the desired compound (yield: 61.0%).

Workup

  1. customThe reaction product was purified

Sources & evidence

ORD record
ord-0342b66cae624a2fa71373dc434a9bf8
Source dataset
uspto-grants-1993_11
Patent number
US05262420

Reaction notes

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