3-Ethyl-4-methylpyridine → 1-(4-Chlorophenyl)-4-(3-ethyl-4-pyridyl)butane

HRID 257484Notes

Reaction equation

HRID 257484 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[CH3:9])[CH3:2].Br[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][CH2:12][CH2:11][CH2:9][C:8]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[CH2:1][CH3:2])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 682543-Ethyl-4-methylpyridineHCID 98811361-(3-Bromopropyl)-4-chlorobenzene

Product 1

HCID 148837921-(4-Chlorophenyl)-4-(3-ethyl-4-pyridyl)butaneYield 56.4%

Procedure

1.83 g (15.1 mmol) of 3-ethyl-4-methylpyridine and 3.53 g (15.1 mmol) of 1-bromo-3-(4-chlorophenyl)-propane were reacted in the same manner as in Example 26. The reaction product was purified to obtain 2.33 g of the desired compound (yield: 56.3%).

Workup

  1. customThe reaction product was purified

Sources & evidence

ORD record
ord-b0627cf7a24347fdb61407cbb4e3793d
Source dataset
uspto-grants-1993_11
Patent number
US05262420

Reaction notes

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