HCID 54081790, compound → HCID 14883837, compound

HRID 257494Notes

Reaction equation

HRID 257494 reaction equation
[C:1]1([CH:7]=[C:8]([CH3:20])[CH2:9][CH:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[CH2:18][CH3:19])[CH3:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.[C].[Pd]>[C:1]1([CH2:7][CH:8]([CH3:20])[CH2:9][CH:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[CH2:18][CH3:19])[CH3:11])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 54081790HCID 54081790, compound2×HCID 178418361HCID 178418361, compound

Product 1

HCID 14883837HCID 14883837, compoundYield 91.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1.2 g (4.53 mmol) of 1-phenyl-2-methyl-4-(3-ethyl-4-pyridyl)-1-pentene (Compound 63) obtained in Example 46 was dissolved in 30 ml of methanol, 250 mg of 5% palladium carbon was added thereto and the resulting mixture was stirred for 8 hours at room temperature in an atmosphere of hydrogen. Palladium-carbon was filtered out and methanol was distilled away under reduced pressure, to obtain 1.1 g (yield: 91.2%) of the desired compound.

Workup

  1. filtrationPalladium-carbon was filtered out and methanol
  2. distillationwas distilled away under reduced pressure

Sources & evidence

ORD record
ord-f6d8647630134125a420bd6ad109342c
Source dataset
uspto-grants-1993_11
Patent number
US05262420

Reaction notes

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