Ethylene Glycol → HCID 54142063, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.4 g (9.8 mM) of [5-(2-benzofuryl) tetrazol-1-yl]acetic acid in 12 ml of ethylene glycol was added 1 ml of sulfuric acid. After the addition, the mixture was stirred at 90° C. for 2.5 hrs. The mixture was then poured into ice-water and the precipitated crystal was filtered off, washed with water and then dissolved in ethyl acetate. The organic solution was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The resultant residue was recrystallized from methyl alcohol, to give 2.14 g (yield 75.4%) of [5-(2-benzofuryl)tetrazol-1-yl]acetic acid 2-hydroxyethyl ester.

Provenance & Evidence