Sulfuric Acid → HCID 54174452, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2 g (9.51 mM) of [5-(3-thienyl)tetrazol-1-yl]acetic acid in 10 ml of 2-methoxyethanol was added 1 ml of sulfuric acid. After the addition, the mixture was stirred at 90° C. for 2.5 hrs. The mixture was then poured into ice-water and extracted with ethyl acetate. The organic phase was washed with water, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The resultant residue was subjected to silica gel column chromatography (eluent: chloroform/ethyl alcohol=30/1) for separation and purification, to give 2.1 g (yield 82.3%) of [5-(3-thienyl)tetrazol-1-yl]acetic acid 2-methoxyethyl ester.

Provenance & Evidence