HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → S-(4-Methylbenzyl)-L-Cysteine t-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isobutylene | HCID 8255 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | S-p-Methylbenzyl-L-cysteine | HCID 13994756 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | S-(4-Methylbenzyl)-L-Cysteine t-Butyl Ester | HCID 14770807 | — |
Reaction Steps
To a cold solution of isobutylene (50 ml) in dioxane (80 ml), add S-(4-methylbenzyl)-L-cysteine (5.0 g) and concentrated H2SO4 (10 ml). Seal the vessel, allow to warm to room temperature, and stir for 18 hr. Pour into 5% NaOH (500 ml), extract with Et2O (3×400 ml), dry (MgSO4) and concentrate the Et2O in vacuo to give an oil. Treat the oil with HCl in Et2O to give the title compound, white needles (2.76 g) m.p. 218° (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05262436 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-df1e9aa54ed6459587d78e86c0be590f |
| Source note | uspto-grants-1993_11 |