2-[(Acetylthio)methyl]-3-phenylpropionic Acid → HCID 14770728, compound

Participants

Reaction Steps

React S-(4-methoxybenzyl)-L-cysteine methyl ester hydrochloride (1.85 g) and 3-acetylthio-2-benzylpropionic acid (1.95 g) in the manner described in Example 1, Step 1 to give an amber oil. Chromatograph this oil on a column of silica gel (2L, 60-200 mesh) and elute with ethyl acetate:hexane 5:20 to give Isomer A, a clear oil (0.63 g), [α]D26 =-66.5° (MeOH), overlap Isomer A and Isomer B (0.28 g); and Isomer B, a clear oil (0.67 g), [α]D26 =+3.0° (MeOH).

Provenance & Evidence