Ammonia → HCID 54465975, compound

Participants

Reaction Steps

The title compound is prepared from 3-(4-bromo-2-fluorobenzyl)-2-methoxyimino-4-oxooctanoyl chloride (from Step G) according to the method of Example 4, Step E, except that instead of bubbling ammonia into the cold reaction mixture, it is preferable to prepare a saturated solution of ammonia in THF (at about -50° C.) and add this cold solution gradually (under protection from moisture) to a stirred solution of the acid chloride in THF at -50° C.

Provenance & Evidence