3-n-Butyl-1-[5-(ethoxycarbonyl)-2-(trifluoromethyl)phenyl]-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-1H-pyrazole-5-carbonitrile → 3-n-Butyl-1-[5-(N-n-butylcarbamoyl)-2-(trifluoromethyl)phenyl]-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-1H-pyrazole-5-carbonitrile

Beteiligte Stoffe

Reaktionsschritte

A solution of 3-n-butyl-1-[5-(ethoxycarbonyl)-2-(trifluoromethyl)phenyl]-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-1H-pyrazole-5-carbonitrile (from Step K) in n-butylamine (approximately 10 mL of amine per mmole of ester) is heated in a sealed tube at 120° C. overnight. Volatiles are removed by evaporation, and the residue is chromatographed on silica gel (elution with CH2Cl2 --MeOH) to provide the title compound.

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