4-Nitro-alpha,alpha,alpha-trifluoro-o-toluidine → 2-Nitro-alpha,alpha,alpha-trifluorotoluene

Participants

Reaction Steps

The precipitate was filtered and air-dried to give 3.5 g (85%) of the product which had a melting point of 85°-89° C. It consisted of 92-93% of the required 4-nitro-2-trifluoromethylaniline which was contaminated with 4-nitro-3-trifluoromethylaniline produced from the 2-trifluoromethylnitrobenzene which had contaminated the starting material. According to 1H-NMR (200 MHz) the product contained less than 1% of the disulphide.

Provenance & Evidence