反应详情

A mixture of methyl 2-[4-[2-(4,5-diphenyl-2oxazolyl]ethyl]phenoxy]acetate (5 g, 12 mmold), 5N sodium hydroxide solution (7.26 mL) and methanol (100 mL) was heated on a steam bath for 45 minutes. The solution was concentrated in vacuo diluted with water and 2N HCl solution an a white solid filtered off. Recrystallization from methanol gave 2-[4-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid (2.88 g, 59%), m.p. 147°-149° C.

1. temperaturewas heated on a steam bath for 45 minutes
2. concentrationThe solution was concentrated in vacuo
3. additiondiluted with water and 2N HCl solution an a white solid
4. filtrationfiltered off
5. customRecrystallization from methanol