Sodium Hydroxide → HCID 10475925, compound

Participants

Reaction Steps

A mixture of ethyl 3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]benzenepropanoate (1.85 g, 4.3 mmol), 3N sodium hydroxide solution (4.4 mL) and methanol (100 mL) was heated on a steam bath. After 20 minutes the mixture was concentrated, diluted with water and 1N hydrochloric acid solution to pH=1 and extracted with CH2Cl2. The combined extracts were dried over sodium sulfate and the solvent evaporated to leave a white solid. Recrystallization from a mixture of hexanes and CH2Cl2 gave 3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]benzenepropanoic acid (1.58 g, 91%) mp 119°-120° C.

Provenance & Evidence