Sodium Hydroxide → 3-[4-[(4,5-Diphenyl-2-oxazolyl)methoxy]phenyl]propanoic Acid

HRID 257631Notes

Reaction equation

HRID 257631 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][C:28]([O:30]C)=[O:29])=[CH:22][CH:21]=3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][O:19][C:20]3[CH:21]=[CH:22][C:23]([CH2:26][CH2:27][C:28]([OH:30])=[O:29])=[CH:24][CH:25]=3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 19783602Methyl 3-[4-[(4,5-diphenyl-2-oxazolyl)methoxy]phenyl]propanoate

Product 1

HCID 197836263-[4-[(4,5-Diphenyl-2-oxazolyl)methoxy]phenyl]propanoic Acid

Procedure

Methyl 3-[4-[(4,5-diphenyl-2-oxazolyl)methoxy]phenyl]propanoate was hydrolyzed with aqueous sodium hydroxide according to the procedure of Example 18 to provide the title compound, m.p. 124°-127° C.

Sources & evidence

ORD record
ord-a52fea7037684d7eba3b1638cd13ebff
Source dataset
uspto-grants-1993_11
Patent number
US05262540

Reaction notes

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