Potassium Iodide → HCID 10342370, compound

Participants

Reaction Steps

A mixture of 3-[2-[4,5-di(3-thienyl)-2-oxazolyl]ethyl]phenol (2.00 g, 5.6 mmol), methyl bromoacetate (1.04 g, 6.8 mmol), potassium carbonate (0.94 g, 6.8 mmol), potassium iodide (catalytic amount) and acetonitrile (100 mL) was stirred at reflux under an atmosphere of nitrogen. After 15 hours, the mixture was cooled, filtered and concentrated and the residue subjected to chromatography on a column of silica gel. Elution with a mixture of hexanes and ethyl acetate (7:2) gave methyl [3-[2-[4,5-di(3-thienyl)-2-oxazolyl]ethyl]phenoxy]acetate (1.95 g, 80%) as an oil.

Provenance & Evidence