HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dodecanoyl chloride → 2,6-Diphenyl-3-methylpiperidin-4-yl Laurate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dodecanoyl chloride | HCID 8166 | — |
| Reactant | 3-Methyl-2,6-diphenyl-4-piperidinol | HCID 2729800 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 2,6-Diphenyl-3-methylpiperidin-4-yl Laurate | HCID 54052528 | 65.3% |
Reaction Steps
The general procedure of Example 1 is repeated using 22.8 g (85.2 mmol) of 2,6-diphenyl-3-methyl-4-hydroxypiperidine, 34 mL (85 mmol) of n-butyllithium (2.5M in hexanes) and 18.6 g (85.2 mmol) of lauroyl chloride. 25.0 g (65% yield) of the title compound is isolated after purification by LC (silica gel, ethyl acetate/hexane): mp 56°-59° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05262538 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-b335ebdc3da842a181e965be321034cb |
| Source note | uspto-grants-1993_11 |