HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Aziridinecarboxamide, N,N-dimethyl- → HCID 19783698, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Aziridinecarboxamide, N,N-dimethyl- | HCID 19470 | — |
| Reactant | 2,6-Difluoropyridine | HCID 73934 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | HCID 19783703 | HCID 19783703 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Tetrahydrofuran hexane | HCID 21883165 | — |
| Product | HCID 19783698 | HCID 19783698 | — |
Reaction Steps
A solution of 0.02 mol of lithium diisopropylamide in THF/hexane (prepared analogously to Example 1) is added dropwise at 25° C. to a mixture of 0.2 mol of 2,6-difluoropyridine, 0.02 mol of N,N-dimethylethyleneurea, 0.02 mol of 2-(4'-propylbicyclohexyl-4-yl)-1-iodoethane and 25 ml of THF. Stirring for 1.5 hours and workup as described in Example 1 give the pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05262556 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-d0850401c4594b03995c52e0bc0b2c5f |
| Source note | uspto-grants-1993_11 |