Triphenylphosphine → HCID 77372954, compound

Participants

Reaction Steps

17-Ethyl-1-hydroxy-12-[2'-(3"-azido-4"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]-octacos-18-ene-2,3,10,16-tetraone (24 mg) in THF (1 ml) containing 1 drop of water was treated with triphenylphosphine (9 mg) and the mixture stirred at room temperature for 72 hours. The reaction mixture was purified directly by preparative thin layer chromatography eluting eith 90% dichloromethane:10% methanol to give the title compound (5 mg, 20%) as a white solid. (1H NMR analysis was consistent with the desired structure).

Provenance & Evidence