HRID2577

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID61230

Diazodiphenylmethane

C13H10N2

结构：COCCOCOc1c(C#N)ccc(C(Br)C(=O)O)c1OCOCCOC

HCID18359186

未命名化合物

PRODUCTS

生成物

结构：COCCOCOc1c(C#N)ccc(C(Br)C(=O)OC(c2ccccc2)c2ccccc2)c1OCOCCOC

HCID53964381

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The product of Step A was dissolved in 10 ml of methylene chloride and 470 mg of diphenyl diazomethane were added. Evaporation was carried out followed by chromatography on silica (eluant: cyclohexane - ethyl acetate (2-1)) to obtain 450 mg of the desired, product.

WORKUP

后处理

customEvaporation
customto obtain 450 mg of the

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9e556f57e168442bbbc24bcb8ff4afba
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05728828
来源说明: uspto-grants-1998_03

反应 SMILES

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([Br:13])[C:10]([OH:12])=[O:11])=[C:5]([O:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH3:20])[C:4]=1[O:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH3:27])#[N:2].[C:28]1([C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[N+]=[N-])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(Cl)Cl>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([Br:13])[C:10]([O:12][CH:34]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:11])=[C:5]([O:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH3:20])[C:4]=1[O:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH3:27])#[N:2]