Benzylamine → HCID 19693234, compound

HRID 257710Notes

Reaction equation

HRID 257710 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH:14]([C:23]([F:26])([F:25])[F:24])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH2:21][CH3:22])=[O:12])=[CH:7][CH:6]=1)(=O)C.C(N)C1C=CC=CC=1>C(O)C.C(Cl)(Cl)Cl>[OH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH:14]([C:23]([F:24])([F:25])[F:26])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH2:21][CH3:22])=[O:12])=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 7504BenzylamineHCID 19105706HCID 19105706, compound

Product 1

HCID 19693234HCID 19693234, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6212ChloroformSolvent

Procedure

The crude product (1.9 g) of the above compound (2) was dissolved in 50 ml of ethanol, and 4 g of benzylamine was added dropwise. Further, after stirring was conducted at room temperature for 4 hours, the mixture was diluted with 500 ml of chloroform, washed with dilute hydrochloric acid and water in this sequence, and dried over magnesium sulfate. After the solvent was evaporated, the residue was isolated and purified by silica gel column chromatography to obtain 1.2 g of a final product (3).

Workup

  1. washwashed with dilute hydrochloric acid and water in this sequence
  2. dry with materialdried over magnesium sulfate
  3. customAfter the solvent was evaporated
  4. customthe residue was isolated
  5. custompurified by silica gel column chromatography

Sources & evidence

ORD record
ord-652877925a8948baa9bc470c8e9c9faa
Source dataset
uspto-grants-1993_11
Patent number
US05264150

Reaction notes

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