Tetrabutylammonium Fluoride → HCID 19380935, compound

Participants

Reaction Steps

To a stirred solution of the silyl ether 30 (27 g, 81 mmol) in THF (270 mL) at ambient temperature was added a premixed solution of n-Bu4NF (1M in THF: 244 mL, 0.24 mol) and AcOH (14 mL, 0.24 mmol) (1:1). After 20 hours the reaction mixture was diluted with ether and then washed with H2O (2 times) and brine, dried (MgSO4), and concentrated to give the alcohol 31 (19 g) as a yellow crystalline solid.

Provenance & Evidence