HCID 19781777, compound → HCID 19781800, compound

HRID 257841Notes

Reaction equation

HRID 257841 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH:26]([C:33]([O:35]C)=[O:34])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[C:21]([CH2:37][CH2:38][CH3:39])[CH:20]=2)[C:7](=[O:17])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])[N:9]=1)[CH2:2][CH2:3][CH3:4]>C(Cl)Cl.CO>[CH2:1]([C:5]1[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH:26]([C:33]([OH:35])=[O:34])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[C:21]([CH2:37][CH2:38][CH3:39])[CH:20]=2)[C:7](=[O:17])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])[N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 19781777HCID 19781777, compound

Product 1

HCID 19781800HCID 19781800, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

This compound was prepared from the product of Step A by the same procedure as for Example 7, Step E. After chromatographic purification, a 50% yield of the title compound was obtained, homogeneous on TLC (9:1 CH2Cl2 /MeOH).

Workup

  1. customAfter chromatographic purification

Sources & evidence

ORD record
ord-08f7177067964b788475e7fcd8829f8c
Source dataset
uspto-grants-1993_11
Patent number
US05264439

Reaction notes

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