Water → 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Sodium hydride	HCID 24758	—
Reactant	Cyclopropanemethanol	HCID 75644	—
Reactant	3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole	HCID 10488164	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine	HCID 19075239	69%

Reaction Steps

To a solution of cyclopropylcarbinol (360 mg, 5 mmol) and sodium hydride (110 mg, 5 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (490 mg, 2.5 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 3 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to yield 400 mg (69%) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05264444
Source dataset	uspto-grants-1993_11
ORD ID	ord-cfdfd04d38a1499fa8a6ef7cf22b3130
Source note	uspto-grants-1993_11