Methyl iodide → 3-(3-(4-Methylpiperidino)-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

HRID 257931Notes

Reaction equation

HRID 257931 reaction equation
[CH3:1][I:2].[CH3:3][CH:4]1[CH2:9][CH2:8][N:7]([C:10]2[C:11]([C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)=[N:12][S:13][N:14]=2)[CH2:6][CH2:5]1>CC(C)=O>[I-:2].[CH3:3][CH:4]1[CH2:5][CH2:6][N:7]([C:10]2[C:11]([C:15]3[CH:16]=[N+:17]([CH3:1])[CH:18]=[CH:19][CH:20]=3)=[N:12][S:13][N:14]=2)[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 190753173-(3-(4-Methylpiperidino)-1,2,5-thiadiazol-4-yl)pyridine

Product 1

HCID 190753753-(3-(4-Methylpiperidino)-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.5 ml, 8 mmol) and 3-(4-(4-methylpiperidino)-1,2,5-thiadiazol-3-yl)pyridine (0.8 g, 3.1 mmol) in acetone (5 ml) was stirred at room temperature for 18 h. The title compound precipitated from the solution and was collected by filtration to yield 1.14 g (92%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration
  3. customto yield 1.14 g (92%)

Sources & evidence

ORD record
ord-afb7f1eb81ea4949b22d1f1d491dfd38
Source dataset
uspto-grants-1993_11
Patent number
US05264444

Reaction notes

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