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HRID257964

反应详情

EQUATION

反应方程式

HRID 257964 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@@H]1C[C@@H](N=[N+]=[N-])CN1C(=O)OC(C)(C)C
HCID11369242

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1C[C@@H](N)CN1C(=O)OC(C)(C)C
HCID7009918

1-tert-Butyl 2-methyl (2S,4R)-4-aminopyrrolidine-1,2-dicarboxylate

C11H20N2O4

收率 92.7%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of (2S,4R)-4-azido-1-t-butoxycarbonyl-2-methoxycarbonylpyrrolidine (112 g) in methanol (870 ml) was hydrogenated under ambient pressure for 5 hours in the presence of 10% palladium on carbon (20.2 g). After removal of the catalyst by filtration, the filtrate was evaporated in vacuo to give (2S,4R)-4-amino-1-t-butoxycarbonyl-2-methoxycarbonylpyrrolidine (93.8 g) as an oil.

WORKUP

后处理

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. customthe filtrate was evaporated in vacuo