HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Kdi 792
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (2S,4R)-2-[(Z)-5-carboxy-1-pentenyl]-4-(4-chlorophenylsulfonylamino)-1-(3-pyridylmethyl)pyrrolidine | HCID 6913587 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Kdi 792 | HCID 6442424 | 178.3% |
Reaction Steps
A solution of (2S,4R)-2-[(Z)-5-carboxy-1-pentenyl]-4-(4-chlorophenylsulfonylamino)-1-(3-pyridylmethyl)pyrrolidine (104 mg) in ethyl acetate (5 ml) was added 1N-hydrogen chloride in ethyl acetate (0.25 ml) and the precipitated brown solid was collected and dried in vacuo to give (2S,4R)-2-[(Z)-5-carboxy-1-pentenyl]-4-(4-chlorophenylsulfonylamino)-1-(3-pyridylmethyl)pyrrolidine hydrochloride (100 mg) as a brown powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05264453 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-ad730c899cb44c168c5f8d5b09d2d1c8 |
| Source note | uspto-grants-1993_11 |