HCID 10966424, compound → HCID 19782198, compound

HRID 258020Notes

Reaction equation

HRID 258020 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:9]2=O)=[CH:5][CH:4]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6](=[CH:5][CH:4]=1)[CH2:7][CH:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:9]2

Participants

4

Reactant 1

HCID 10966424HCID 10966424, compound

Product 1

HCID 19782198HCID 19782198, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

32.0 g (0.145 mol) of ethyl 6-methoxy-indan-1-one-2-carboxylate [cf. H. O. House, C. B. Hudson, J. Org. Chem. 35 (1970) 3, 647-651] are hydrogenated with 20 bar of H2 at 50° C. for 5 h in 180 ml of MeOH in the presence of 5 g of palladium/carbon (5% strength) as a catalyst. The catalyst is filtered off, the methanol is stripped off in vacuo and the residue is distilled in a bulb tube furnace.

Workup

  1. filtrationThe catalyst is filtered off
  2. distillationthe residue is distilled in a bulb tube furnace

Sources & evidence

ORD record
ord-c28d0a880591461bb3dcfaa788f344b5
Source dataset
uspto-grants-1993_11
Patent number
US05264458

Reaction notes

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