Methanol → HCID 19782203, compound

Participants

Reaction Conditions

Reaction Steps

4.98 g (19.2 mmol) of the compound from Example 15 are dissolved in 38 ml of CH2Cl2 and 19 ml of absolute MeOH and 4.35 g (21.1 mmol) of dicyclohexylcarbodiimide and 20 ml of dimethylaminopyridine are added at 0° C. The mixture is allowed to come to room temperature and is stirred at 20° C. for 2 h. Precipitated dicyclohexylurea is filtered off and washed well with CH2Cl2, and the combined CH2Cl2 phases are washed twice with 1N NaOH solution, once with 1N hydrochloric acid and once with NaCl solution. After drying over Na2SO4, the solution is evaporated and the residue is flash chromatographed on silica gel (eluent: methylene chloride)

Provenance & Evidence