HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenol → Toluene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | 3-Chloropropionyl chloride | HCID 69364 | — |
| Product | Toluene | HCID 1140 | 86.1% |
| Product | 4-Fluoro-7-hydroxy-2,3-dihydro-1H-inden-1-one | HCID 15268488 | — |
Reaction Steps
4-Fluoro-7-hydroxy-indan-1-one is prepared in analogy to the non-fluorinated compound by the process of S. Wagatsuma et al. [Org. Prep. Proced. Int., 5(2), 1973, 65-70] in two steps: 1. esterification of 4-fluorophenol and 3-chloropropionyl chloride by refluxing both components in toluene (yield: 86.1%, b.p: 150° C./30 mm); 2. heating the ester in the presence of AlCl3 (yield: 53.9%, m.p.: 87° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05264458 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-67f055399c3b45808e10e7359f97f5b8 |
| Source note | uspto-grants-1993_11 |