Ethyl 4-fluoro-2,3-dihydro-7-hydroxy-1-oxo-1H-indene-2-carboxylate → HCID 19782179, compound

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Reaction Steps

94 g (0.4 mol) of the compound from Example 26 are hydrogenated in 600 ml of ethanol using 20 g of Pd-C (5% strength) at 30 bar of H2 and 60° C. for 4 h. The catalyst is filtered off, the solution is evaporated and the residue is flash chromatographed on silica gel (eluent: petroleum ether/acetone 5:1). After evaporating the fractions containing the product, the residue is recrystallized from ligroin.

Provenance & Evidence