2,4-Difluorophenyl isocyanate → N-[4-(2-chlorophenyl)-7,8-dihydro-6H-cyclopenta[g]quinolin-3-yl]-N'-(2,4-difluorophenyl)urea

関与物質

反応手順

To a solution of 3-amino-4-(2-chlorophenyl)-7,8-dihydro-6H-cyclopenta[g]quinoline (2.5 g) in tetrahydrofuran (25 ml) was added 2,4-difluorophenyl isocyanate (1.2 ml) dropwise and the mixture was stirred for 5 hours at room temperature. The solvent was then distilled off to give crystals of N-[4-(2-chlorophenyl)-7,8-dihydro-6H-cyclopenta[g]quinolin-3-yl]-N'-(2,4-difluorophenyl)urea. The crystals were collected by filtration and washed with isopropyl ether (3.42 g, 89.8%). Recrystallization from acetic acid-water gave colorless needles, m.p. 247°-248° C.

情報源と証拠