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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 25803Generated: October 25, 2026

2-Phenylethanethiol → 2,2-Dimethyl-6-(2-methylsulfanylphenyl)-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

https://huagongshe.com/reaction/25803

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-PhenylethanethiolHCID 78126—
Reactant2-(Methylthio)benzeneboronic acidHCID 2773543—
ReactantTrifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl esterHCID 20760320—
Product2,2-Dimethyl-6-(2-methylsulfanylphenyl)-4-phenethylsulfanylmethyl-1,2-dihydroquinolineHCID 10455467—

Reaction Steps

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 2-(methylthio)phenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 59 mg of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06858627B2
Source datasetuspto-grants-2005_02
ORD IDord-7038e07fd43c47049bcde43c3da206c3
Source noteuspto-grants-2005_02