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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 25804Generated: October 26, 2026

2-Phenylethanethiol → 6-(2,5-Dimethoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

https://huagongshe.com/reaction/25804

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-PhenylethanethiolHCID 78126—
Reactant2,5-Dimethoxyphenylboronic acidHCID 2734342—
ReactantTrifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl esterHCID 20760320—
Product6-(2,5-Dimethoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinolineHCID 10343495—

Reaction Steps

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 2,5-dimethoxyphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 43 mg of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06858627B2
Source datasetuspto-grants-2005_02
ORD IDord-c246b091f79b4c109a44240105e7ca29
Source noteuspto-grants-2005_02