HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → HCID 19936582, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 19936572 | HCID 19936572 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 19936582 | HCID 19936582 | 98.1% |
Reaction Steps
A mixture of 5-amino-6-(2-methylbenzoyl)indan (5.02 g), diethyl malonate (6.4 g) and DBU (0.3 ml) was heated at 170°-180° C. for 1 hour. To this reaction mixture was added ethanol to give crystals of ethyl 4-(2-methylphenyl)-2-oxo-1,2,7,8-tetrahydro-6H-cyclopenta[g]quinoline-3-carboxylate (6.81 g, 98.1%). Recrystallization from ethanol-chloroform gave colorless crystals, m.p. 296°-298° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05264454 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-a4d4807e73f34052a15ef1b2fc98e33e |
| Source note | uspto-grants-1993_11 |