反应详情

To a solution of 5-(3,5-di-tert-butyl-4-hydroxybenzoyl)-6-methoxyindan (3.8 g) in dichloromethane (30 ml) was added boron tribromide-dichloromethane (1:2, 3 ml) dropwise with ice-cooling and stirring. The mixture was stirred under ice-cooling for 15 minutes, after which ethanol (5 ml) was added dropwise. The mixture was then washed with water and dried (MgSO4) and the solvent was distilled off. To the residue was added hexane to give crystals of 5-(3,5-di-tert-butyl-4-hydroxybenzoyl)-6-hydroxyindan (3.06 g, 83.6%). Recrystallization from ethanol gave light yellow prisms, m.p. 155°-156° C.

1. temperaturecooling
2. stirringThe mixture was stirred under ice-
3. temperaturecooling for 15 minutes
4. washThe mixture was then washed with water
5. dry with materialdried (MgSO4)
6. distillationthe solvent was distilled off
7. additionTo the residue was added hexane